Our research includes: 1) stem cell systems focused on restoring sight in people with macular degeneration and various retinal disorders together with glaucoma and a pair of) cell delivery technologies to transplant practical cells to ideal places.
Our exploration consists of the identification of most cancers stem cells in lung squamous cell carcinoma and focusing on of such stem cells in preclinical chemotherapeutic trials.
My team has an interest in comprehending the pores and skin pigmentary system as well as prospective position of melanocyte stem cells in hyperpigmentation and in pigmentation diseases for instance vitiligo or premature graying the place melanocyte reduction is noticed. We've been focused on getting successful therapies for these ailments.
My lab operates extensively with embryonic stem cells, investigating the mechanisms that advertise pluripotency.
We are presently finding out the position of critical oncogenic and tumor suppressor pathways, notably p53, in melanoma progression and metastatic conversion through their consequences on stem-like Homes of melanoma cells.
The key target of our exploration software would be to know how neural crest progenitor stem cells become differentiated cell populations, which include neurons, glia and melanocytes (pigment cells) throughout progress.
After A prosperous method for his ailing knee, Nadal returned to remarkably competitive tennis, logging many a lot more significant wins. When he made side dysfunction in his lumbar backbone, he was in a position to speedily return to participating in kind, once again, pursuing stem cell treatment.
A current pilot study assessing the use of Grownup stem cells for your treatment of knee osteoarthritis used MRI information along with soreness reduction To guage treatment success.
We review how the regulation of mitosis, which governs the physiological roles of epithelial stem cells in advancement and tissue homeostasis, is altered in human diseases affiliated with irregular cellular advancement like most cancers.
Minimally invasive: Stem cell treatments are done within an office-primarily based process suite and lead to small tissue problems.
The Regenerative Neurobiology Laboratory research novel mechanisms of neurological recovery following gene therapy, stem cell transplant and organelle transfer subsequent world-wide cerebral ischemia.
Disorders like age-linked macular degeneration and diabetic retinopathy may cause photoreceptors to die. This ends in long lasting eyesight loss because rods and cones are not able to regenerate.
The delivery of a large volume of stem cells by injection may help initiate the therapeutic reaction. Stem cell therapy can maintenance degenerative knee cartilage, partly torn tendons, and supply pain relief when conservative treatments had been unsuccessful.
For ADAM10 studies, we have been investigating the role of ADAM10-mediated Notch signaling while in the intestinal stem cell specialized niche, cell lineage programming As well as in colon cancer versions. For top article ADAM17 scientific tests, we've been studying the part of ADAM17-mediated ErbB signaling in intestinal harm/repair and inflammation designs. Our reports use genetic mouse styles and intestinal stem cell enteroid tradition systems to check these signaling activities.